2C-x phenethylamines2C-B, 2C-I, 2C-E

Clinical contraindication: None listed; No clinical contraindication identified.
Best available evidence: Mechanism only
Half-life: Not recorded

Named in state rules?

CONot named

ORNot named

NMPending

Cite asPsilodex: 2c-phenethylamines · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Act at the same 5-HT2A receptor as psilocin, so additive effects and possible cross-tolerance are expected. 2C-B raises heart rate and blood pressure. 'Tusi' or 'pink cocaine' usually contains ketamine and MDMA, not 2C-B.

Human data with psilocybin: None known: no published human data with psilocybin

Evidence types on this record

ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Raises blood pressure or heart rate: Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

Papaseit E, Farré M, Pérez-Mañá C, et al. Acute pharmacological effects of 2C-B in humans: an observational study. Front Pharmacol 2018;9:206. — 5-HT2A/2B/2C partial agonist; BP and HR rose in humans
Abukahok N, Fitzgerald ND, Palamar JJ. An update on the epidemiology of tusi ("pink cocaine"). Curr Addict Rep 2025;12. — tusi typically ketamine + MDMA, variable additives

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