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Reviewed 2026-10-02

4-AcO-DMT (psilacetin)

psilodex.org/m/4-aco-dmt · data v2026.10.02

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Mechanism only
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: 4-aco-dmt · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Th

Synthetic psilocin prodrug: deacetylated to psilocin, the same active compound psilocybin yields, so tolerance and additive effects are expected. It has turned up undeclared in mushroom gummies. Recent use may blunt the session dose.

Human data with psilocybin
None known: no published human data with psilocybin
Evidence types on this record
ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

None listed

No pharmacology properties of concern are listed for this record.

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

3
  1. Jones NT, Wagner L, Hahn MCP, Scarlett CO, Wenthur CJ. In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybin. Front Psychiatry 2024;14:1303365. — psilacetin is a psilocin prodrug; ~70% of psilocybin's psilocin exposure (mice)
  2. Glatfelter GC, Pottie E, Partilla JS, et al. Structure–activity relationships for psilocybin, baeocystin, aeruginascin, and related analogues to produce pharmacological effects in mice. ACS Pharmacol Transl Sci 2022;5(11):1181–1196. — psilacetin a psilocin prodrug with its own 5-HT receptor activity; 5-HT2A-dependent head twitch
  3. Correia MS, Gonzaga MJ, Temple C, Gerona RR. Quantitative analysis of recreational psychoactive mushroom gummies in Portland, Oregon. Clin Toxicol (Phila) 2025;63(4):261-266. — 6 of 8 'mushroom' gummies contained 4-AcO-DMT

Record history

  • v2026.10.02First published.
  • 2026-10-02Last reviewed against its sources.

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