Betel nut / areca nut

psilodex.org/m/betel-areca · data v2026.10.02

Clinical contraindication: None listed; No clinical contraindication identified.
Best available evidence: Mechanism only
Half-life: Not recorded

Named in state rules?

CONot named

ORNot named

NMPending

Cite asPsilodex: betel-areca · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Areca nut's main alkaloid, arecoline, is cholinergic (parasympathomimetic). Betel chewing raises heart rate, blood pressure and body temperature, increases catecholamines, and can lead to dependence and withdrawal. No psilocybin-specific data.

Human data with psilocybin: None known: no published human data with psilocybin

Evidence types on this record

ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Raises blood pressure or heart rate: Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

Chu NS. Effects of betel chewing on the central and autonomic nervous systems. J Biomed Sci 2001;8(3):229–236. — betel chewing increases HR, BP, sweating, temperature and plasma catecholamines; habituation and withdrawal

Record history

v2026.10.02First published.
2026-10-02Last reviewed against its sources.

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