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PsilodexMedication × psilocybin
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Peptides
Brand names
CagriSema
Reviewed 2026-10-01

Cagrilintide–semaglutide

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Mechanism only
Also: standard practice.
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: cagrilintide-semaglutide · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Th · Pr

Both components slow gastric emptying, which can delay or reduce absorption of oral psilocybin and add to nausea. Semaglutide component: ~1-week half-life.

Human data with psilocybin
None known: no published human data with psilocybin
Common practice
GLP-1 receptor agonists slow gastric emptying, which can delay or reduce absorption of orally taken medicines, including psilocybin, and add to its nausea.

No peptide in this section has published human data on interaction with psilocybin or any classic psychedelic. Entries rest on each agent's own pharmacology, and many have no human pharmacokinetic data at all. For unapproved products the larger practical concern is unknown content, dose and sterility. Regulatory status changes quickly (FDA compounding actions in 2026); check the date on each entry.

Evidence types on this record
ThMechanism only (theoretical)
PrStandard practice; no psilocybin-specific data

02 Pharmacology relevant to psilocybin

1 listed · counted on reports
Slows gastric emptying
Slows how quickly the stomach empties. Can delay or change the onset of a dose taken by mouth and add to nausea. Sources [1]

03 State rules

Official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

1
  1. Singhani V, et al. Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: a narrative expert review. Nutr Clin Pract 2026;41(5):1318–1333.

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It describes published evidence and state rules. It is not medical advice, a screening decision, or clearance to participate.
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