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PsilodexMedication × psilocybin
Your list 00
Other substances
Brand names
—
Reviewed 2026-10-02

CannabisTHC

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Case reports
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: cannabis · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

CR

In a prospective survey, cannabis used alongside classic psychedelics was linked to more intense experiences in a dose-dependent way, with a non-linear link to challenging-experience scores. THC raises heart rate and blood pressure and can provoke anxiety or panic.

Human data with psilocybin
Case reports or surveys only
Common practice
Many programs ask participants to pause cannabis for a day or more before dosing.
Evidence types on this record
CRCase reports or online surveys

02 Pharmacology relevant to psilocybin

1 listed · counted on reports
Raises blood pressure or heart rate
Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [2]

03 State rules

Official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

2
  1. Kuc J, Kettner H, Rosas F, et al. Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey. Psychopharmacology (Berl) 2022;239(5):1425–1440. — n=321; linear dose relationship with MEQ, ASC-Vis and EDI; quadratic with CEQ
  2. National Institute on Drug Abuse (NIDA), NIH. Research-topic pages (per-entry link). — heart rate and blood pressure rise right after use; psychosis link in people at genetic risk

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It describes published evidence and state rules. It is not medical advice, a screening decision, or clearance to participate.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
  3. 03Your list stays in this browser. Nothing you enter is sent anywhere.

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