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PsilodexMedication × psilocybin
Your list 00
Psychotropics
Brand names
Klonopin
Reviewed 2026-09-30

Clonazepam

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Standard practice
Half-life
30–40 h
Approximate, in adults. Detail in 01.
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: clonazepam · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Pr

GABAergic blunting; stopping daily use abruptly risks withdrawal seizures.

Human data with psilocybin
None known: no published human data with psilocybin
Common practice
Daily use carries withdrawal risk if stopped abruptly. Any change is the prescriber's decision.
Half-life
30–40 h (FDA label, checked 2026-09-30)
Evidence types on this record
PrStandard practice; no psilocybin-specific data

02 Pharmacology relevant to psilocybin

2 listed · counted on reports
Sedating or CNS depressant
Slows the central nervous system: drowsiness, slower reactions and impaired coordination, and slowed breathing at high doses. Effects add with other sedating substances. Sources [1]
Withdrawal or rebound if stopped abruptly
Stopping suddenly can cause withdrawal or a rebound of symptoms. Any change to the dose is the prescriber’s decision. Sources [1]

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

  • Seizure disorder or bipolar disorder (possible indications)CO 2.5(A)(2)

05 Sources

1
  1. KLONOPIN ® TABLETS (clonazepam) · FDA label (DailyMed)

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01Psilodex summarizes published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
  3. 03Your searches and list stay in this browser and are not sent to us. Opening a medication's page is an ordinary web request, so our hosting providers see which page was opened. What we can and can't see.

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