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PsilodexMedication × psilocybin
Your list 00
Psychotropics
Brand names
Norpramin
Reviewed 2026-10-01

Desipramine

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Other psychedelic
Also: mechanism only.
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: desipramine · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

XP · Th

Noradrenergic BP/heart rate rise; seizure threshold, QTc, arrhythmia risk. With LSD, chronic imipramine, desipramine or clomipramine increased the response in all 5 people interviewed (Bonson & Murphy 1996).

Human data with psilocybin
None with psilocybin; human data with another psychedelic
Evidence types on this record
XPHuman data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text
ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

3 listed · counted on reports
QT-prolonging
Lengthens the QT interval on an ECG, a measure of the heart’s electrical recovery between beats. A long QT raises the risk of a dangerous heart rhythm, more so with other QT-prolonging drugs or low potassium or magnesium. Sources [1]
Raises blood pressure or heart rate
Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]
Lowers seizure threshold or carries seizure risk
Makes a seizure more likely, or has been linked to seizures. Sources [1]

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

2
  1. Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinki · FDA label (DailyMed)
  2. Bonson KR, Murphy DL. Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium. Behav Brain Res 1996;73:229–233. — LSD; n=5 on TCAs, all increased

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It summarises published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
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