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PsilodexMedication × psilocybin
Your list 00
General prescriptions
Brand names
Duragesic
Reviewed 2026-09-30

Fentanyl

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Mechanism only
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: fentanyl · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Th

Serotonergic opioid; sedation and respiratory depression stack.

Human data with psilocybin
None known: no published human data with psilocybin
Evidence types on this record
ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

2 listed · counted on reports
Sedating or CNS depressant
Slows the central nervous system: drowsiness, slower reactions and impaired coordination, and slowed breathing at high doses. Effects add with other sedating substances. Sources [1]
Serotonergic
Increases serotonin activity, for example by blocking its reuptake or releasing it. Psilocybin acts on serotonin receptors, so effects can add together. With antidepressant use, the psilocybin response can be weaker. Sources [2]

03 State rules

Official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

  • Severe chronic illnessCO 2.5(A)(2)

05 Sources

2
  1. Abstral (Fentanyl Citrate) Tablet · FDA label (DailyMed)
  2. Preston CL (ed). Stockley’s Drug Interactions, 11th ed. Pharmaceutical Press, 2016., p. 236

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It describes published evidence and state rules. It is not medical advice, a screening decision, or clearance to participate.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
  3. 03Your list stays in this browser. Nothing you enter is sent anywhere.

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