Indomethacin

psilodex.org/m/indomethacin · data v2026.10.02

Clinical contraindication: None listed; No clinical contraindication identified.
Best available evidence: Standard practice
Half-life: Not recorded

Named in state rules?

CONot named

ORNot named

NMPending

Cite asPsilodex: indomethacin · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Can cause new or worsened hypertension. The label notes it may aggravate depression or other psychiatric disturbances, epilepsy and parkinsonism. No direct psilocybin interaction data.

Human data with psilocybin: None known: no published human data with psilocybin

Evidence types on this record

PrStandard practice; no psilocybin-specific data

02 Pharmacology relevant to psilocybin

2 listed · counted on reports

Raises blood pressure or heart rate: Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]
Lowers seizure threshold or carries seizure risk: Makes a seizure more likely, or has been linked to seizures. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

Indomethacin Capsule · FDA label (DailyMed) — 5.4 hypertension; 5.15 CNS effects (aggravates epilepsy, psychiatric disturbances); convulsions listed in adverse reactions

Record history

v2026.10.02First published.
2026-10-02Last reviewed against its sources.

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