PsilodexMedication × psilocybin
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Other substances
Brand names
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Reviewed 2026-10-02

Inhalants (solvents, fuels, aerosols)

psilodex.org/m/inhalants · data v2026.10.02

Clinical contraindication
Relative
Substantial clinical concern; the literature treats it as a reason for caution or deferral.
Best available evidence
Case reports
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: inhalants · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

CR

Volatile solvents, fuels and aerosol propellants depress the central nervous system. Sudden sniffing death can follow a single session, from cardiac arrhythmia or asphyxia, especially with butane, propane and aerosols. No psilocybin-specific data; nitrous oxide and poppers have separate records.

Human data with psilocybin
Case reports or surveys only
Evidence types on this record
CRCase reports or online surveys

02 Pharmacology relevant to psilocybin

1 listed · counted on reports
Sedating or CNS depressant
Slows the central nervous system: drowsiness, slower reactions and impaired coordination, and slowed breathing at high doses. Effects add with other sedating substances. Sources [3]

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

3
  1. US Drug Enforcement Administration. Drug Fact Sheets (per-entry link). — sudden sniffing death after a single session, esp. butane, propane, aerosols; huffing, bagging
  2. El Balkhi S, Coutaz-Fluck C, Moreau F, Paraf F, Gaulier JM. Is it worth carrying out determination of N-butane in postmortem samples? A case report and a comprehensive review of the literature. Int J Legal Med 2016;130(5):1223–1229. — butane deaths from asphyxia and/or cardiac arrhythmia
  3. Da Broi U, Colatutto A, Sala P, Desinan L. Medico legal investigations into sudden sniffing deaths linked with trichloroethylene. J Forensic Leg Med 2015;34:81–87. — solvent sniffing: CNS depression, coma, cardiorespiratory arrest

Record history

  • v2026.10.02First published.
  • 2026-10-02Last reviewed against its sources.

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01Psilodex summarizes published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
  3. 03Your searches and list stay in this browser and are not sent to us. Opening a medication's page is an ordinary web request, so our hosting providers see which page was opened. What we can and can't see.

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