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PsilodexMedication × psilocybin
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Psychotropics
Brand names
Lamictal
Reviewed 2026-09-30

Lamotrigine

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Case reports
Half-life
25.4 h
Approximate, in adults. Detail in 01.
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: lamotrigine · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

CR

In 34 online reports of lamotrigine with a classic psychedelic, none described a seizure; most reported no effect on the experience (Nayak 2021).

Human data with psilocybin
Case reports or surveys only
Half-life
25.4 h monotherapy (multiple dose; range 11.6–61.6 h). With valproate ~70 h; with enzyme inducers (carbamazepine, phenytoin, phenobarbital, primidone) ~13 h (FDA label, checked 2026-10-01)
Evidence types on this record
CRCase reports or online surveys

02 Pharmacology relevant to psilocybin

None listed

No pharmacology properties of concern are listed for this record.

03 State rules

Official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

  • Seizure disorder or bipolar disorder (possible indications)CO 2.5(A)(2)

05 Sources

2
  1. Lamotrigine Tablet · FDA label (DailyMed)
  2. Nayak SM, Gukasyan N, Barrett FS, et al. Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures. Pharmacopsychiatry 2021.

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It describes published evidence and state rules. It is not medical advice, a screening decision, or clearance to participate.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
  3. 03Your list stays in this browser. Nothing you enter is sent anywhere.

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