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PsilodexMedication × psilocybin
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Psychotropics
Brand names
Lithobid
Reviewed 2026-10-01

Lithium

Clinical contraindication
Absolute
The clinical literature treats the combination as contraindicated.
Best available evidence
Case reports
Also: other psychedelic.
Half-life
18–36 h
Approximate, in adults. Detail in 01.
Named in state rules?
CONamed
ORNamed
NMPending
Cite asPsilodex: lithium · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

CR · XP

In 62 online reports of lithium with a classic psychedelic, 47% described seizures and 39% needed medical attention (Nayak 2021). With LSD, chronic lithium (alone or with imipramine) intensified effects in all 3 people interviewed (Bonson & Murphy 1996).

Human data with psilocybin
Case reports or surveys only
Half-life
18–36 h (FDA label, checked 2026-09-30)
Evidence types on this record
CRCase reports or online surveys
XPHuman data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text

02 Pharmacology relevant to psilocybin

2 listed · counted on reports
Lowers seizure threshold or carries seizure risk
Makes a seizure more likely, or has been linked to seizures. Sources [1]
Serotonergic
Increases serotonin activity, for example by blocking its reuptake or releasing it. Psilocybin acts on serotonin receptors, so effects can add together. With antidepressant use, the psilocybin response can be weaker. Sources [1]

03 State rules

Official text governs
CO4 CCR 755-1
Named · 2.2(A)(6)–(7) · 2.5(A)(2)

Lithium is named in rule. A Facilitator licensee may not provide services to a participant taking lithium without a referral for natural medicine services from a licensed provider, medical clearance from their medical or behavioral health provider, or a consultation and risk review with a medical or behavioral health provider. A Clinical Facilitator who does not prescribe lithium within their secondary license needs clearance from, or a consultation and risk review with, such a provider.

Colorado · checked 2026-09-30
OROAR 333-333
Named · 333-333-5050(3)(a)

Lithium is named on Oregon's required Client Information Form. A client who has taken lithium in the last 30 days may not participate in an administration session.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

  • Bipolar disorder (common indication)CO 2.2(A)(6)–(7) · CO 2.5(A)(2)

05 Sources

4
  1. Lithium — prescribing information · FDA label (DailyMed)
  2. Nayak SM, Gukasyan N, Barrett FS, et al. Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures. Pharmacopsychiatry 2021.
  3. Bonson KR, Murphy DL. Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium. Behav Brain Res 1996;73:229–233.
  4. Halman A, Kong G, Sarris J, Perkins D. Drug–drug interactions involving classic psychedelics: a systematic review. J Psychopharmacol 2024;38(1):3–18.

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It describes published evidence and state rules. It is not medical advice, a screening decision, or clearance to participate.
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