PsilodexMedication × psilocybin
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Supplements and over the counter
Brand names
Imodium, Imodium A-D
Reviewed 2026-10-02

Loperamide

psilodex.org/m/loperamide · data v2026.10.02

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Mechanism only
Half-life
~10.8 h
Approximate, in adults. Detail in 01.
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: loperamide · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Th

At recommended doses central opioid effects are minimal. At higher than recommended doses, including misuse to self-treat opioid withdrawal, QT prolongation, torsades de pointes, cardiac arrest and death are reported; risk rises with other QT-prolonging drugs or CYP3A4/P-glycoprotein inhibitors.

Human data with psilocybin
None known: no published human data with psilocybin
Half-life
~10.8 h (range 9.1–14.4 h) (FDA label, checked 2026-10-02)
Evidence types on this record
ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

1 listed · counted on reports
QT-prolonging
Lengthens the QT interval on an ECG, a measure of the heart’s electrical recovery between beats. A long QT raises the risk of a dangerous heart rhythm, more so with other QT-prolonging drugs or low potassium or magnesium. Sources [1]

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

2
  1. Loperamide Hydrochloride Capsule (Mylan, Rx) · FDA label (DailyMed) — Boxed warning: torsades de pointes and sudden death with higher than recommended doses; Drug Abuse and Dependence: misuse for opioid withdrawal
  2. Imodium A-D (Loperamide Hydrochloride) Capsule, Liquid Filled — Drug Facts · FDA label (DailyMed) — Heart alert: taking more than directed can cause serious heart problems or death

Record history

  • v2026.10.02First published.
  • 2026-10-02Last reviewed against its sources.

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01Psilodex summarizes published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
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