LSD

Clinical contraindication: None listed; No clinical contraindication identified.
Best available evidence: Other psychedelic; Human data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text.
Half-life: Not recorded

Named in state rules?

CONot named

ORNot named

NMPending

Cite asPsilodex: lsd · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Human studies show cross-tolerance between LSD and psilocybin: recent LSD use blunts the psilocybin response. Taken together the effects are expected to be additive; LSD also raises heart rate and blood pressure.

Human data with psilocybin: None with psilocybin; human data with another psychedelic

Evidence types on this record

XPHuman data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Raises blood pressure or heart rate: Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [2]

03 State rules

Official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

Isbell H, Wolbach AB, Wikler A, Miner EJ. Cross tolerance between LSD and psilocybin. Psychopharmacologia 1961;2:147–159. — LSD–psilocybin cross-tolerance in humans
US Drug Enforcement Administration. Drug Fact Sheets (per-entry link).

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