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PsilodexMedication × psilocybin
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Other substances
Brand names
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Reviewed 2026-10-02

Mescaline / peyote / San Pedro

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Other psychedelic
Human data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text.
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: mescaline · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

XP

Human studies show cross-tolerance between mescaline and LSD, and between LSD and psilocybin, so recent mescaline use may blunt psilocybin. Nausea and raised heart rate, blood pressure and body temperature are common.

Human data with psilocybin
None with psilocybin; human data with another psychedelic
Evidence types on this record
XPHuman data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text

02 Pharmacology relevant to psilocybin

1 listed · counted on reports
Raises blood pressure or heart rate
Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [3]

03 State rules

Official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

3
  1. Wolbach AB, Isbell H, Miner EJ. Cross tolerance between mescaline and LSD-25, with a comparison of the mescaline and LSD reactions. Psychopharmacologia 1962;3:1–14. — mescaline–LSD cross-tolerance in humans
  2. Isbell H, Wolbach AB, Wikler A, Miner EJ. Cross tolerance between LSD and psilocybin. Psychopharmacologia 1961;2:147–159. — LSD–psilocybin cross-tolerance
  3. US Drug Enforcement Administration. Drug Fact Sheets (per-entry link).

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Before you startTerms v2026-10-01

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  1. 01It describes published evidence and state rules. It is not medical advice, a screening decision, or clearance to participate.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
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