Paliperidone

Clinical contraindication: Relative; Substantial clinical concern; the literature treats it as a reason for caution or deferral.
Best available evidence: Mechanism only
Half-life: ~23 h; Approximate, in adults. Detail in 01.

Named in state rules?

CONamed

ORNot named

NMPending

Cite asPsilodex: paliperidone · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

5-HT2A/D2 blockade blunts effects; LAI persists for months.

Human data with psilocybin: None known: no published human data with psilocybin
Half-life: oral ER ~23 h; Invega Sustenna 25–49 days (FDA label, checked 2026-09-30)

Evidence types on this record

ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Blocks 5-HT2A (may blunt effects): Blocks the 5-HT2A receptor, the main receptor psilocybin acts through. Can reduce or block the psilocybin effect. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Named · 2.2(A)(6)–(7) · 2.5(A)(2)

Antipsychotic medications are named in rule, regardless of indication or dose. A Facilitator licensee may not provide services to a participant taking one without a referral for natural medicine services from a licensed provider, medical clearance from their medical or behavioral health provider, or a consultation and risk review with a medical or behavioral health provider. A Clinical Facilitator who does not prescribe antipsychotics within their secondary license needs clearance from, or a consultation and risk review with, such a provider.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

Psychotic disorder or bipolar disorder (common indications)CO 2.2(A)(6)–(7) · CO 2.5(A)(2) · OR 333-333-5050(3)(j)

05 Sources

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