Prochlorperazine

Clinical contraindication: Relative; Substantial clinical concern; the literature treats it as a reason for caution or deferral.
Best available evidence: Mechanism only
Half-life: Not recorded

Named in state rules?

COUnsettled

ORNot named

NMPending

Cite asPsilodex: prochlorperazine · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Phenothiazine D2 blocker; may blunt effects.

Human data with psilocybin: None known: no published human data with psilocybin

Evidence types on this record

ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

None listed

No pharmacology properties of concern are listed for this record.

03 State rules

Official text governs

CO4 CCR 755-1

Unsettled · 2.2(A)(6)–(7)

Whether this drug counts as an “antipsychotic” under the rule is unsettled: it is a phenothiazine or has antipsychotic-like activity but is usually prescribed for another purpose. Programs differ on whether the antipsychotic provision applies.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

Prochlorperazine Maleate Tablet Prochlorperazine Maleate Tablet · FDA label (DailyMed)

Report an error in this record →