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PsilodexMedication × psilocybin
Your list 00
General prescriptions
Brand names
Bactrim
Reviewed 2026-09-30

Sulfamethoxazole-trimethoprim

Clinical contraindication
None listed
No clinical contraindication identified.
Best available evidence
Standard practice
Half-life
Not recorded
Named in state rules?
CONot named
ORNot named
NMPending
Cite asPsilodex: sulfamethoxazole-trimethoprim · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Pr

No known interaction.

No reported interaction is not a finding of safety: most combinations with psilocybin have never been studied. Whether this combination suits a particular person is for their prescriber and provider to decide.

Human data with psilocybin
None known: no published human data with psilocybin
Evidence types on this record
PrStandard practice; no psilocybin-specific data

02 Pharmacology relevant to psilocybin

None listed

No pharmacology properties of concern are listed for this record.

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

3
  1. Bactrim Ds (Sulfamethoxazole And Trimethoprim) Tablet Bactrim (Sulfamethoxazole And Trimet · FDA label (DailyMed)
  2. Halman A, Kong G, Sarris J, Perkins D. Drug–drug interactions involving classic psychedelics: a systematic review. J Psychopharmacol 2024;38(1):3–18. — no reported interaction
  3. Sarparast A, Thomas K, Malcolm B, Stauffer CS. Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review. Psychopharmacology 2022;239(6):1945–1976. — no reported interaction

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It summarises published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
  3. 03Your searches and list stay in this browser and are not sent to us. What we can and can't see.

In an emergency, call 911. Full terms and privacy.