Synthetic cathinones ("bath salts")

psilodex.org/m/synthetic-cathinones · data v2026.10.02

Clinical contraindication: Relative; Substantial clinical concern; the literature treats it as a reason for caution or deferral.
Best available evidence: Case reports; Also: mechanism only.
Half-life: Not recorded

Named in state rules?

CONot named

ORNot named

NMPending

Cite asPsilodex: synthetic-cathinones · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

CR · Th

Amphetamine-like stimulants, some also acting on serotonin. Poisonings involve rapid heartbeat, hypertension, hyperthermia, seizures, agitation and psychosis; mephedrone, MDPV and methylone appear in serotonin syndrome reports. Product contents vary widely. No psilocybin-specific data.

Human data with psilocybin: Case reports or surveys only

Evidence types on this record

CRCase reports or online surveys

ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

3 listed · counted on reports

Serotonergic: Increases serotonin activity, for example by blocking its reuptake or releasing it. Psilocybin acts on serotonin receptors, so effects can add together. With antidepressant use, the psilocybin response can be weaker. Sources [2][3]
Raises blood pressure or heart rate: Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]
Lowers seizure threshold or carries seizure risk: Makes a seizure more likely, or has been linked to seizures. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

US Drug Enforcement Administration. Drug Fact Sheets (per-entry link). — rapid heartbeat, hypertension, hyperthermia, seizures; psychosis, agitation
Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol 2012;8(1):33–42. — amphetamine-like properties and ability to modulate serotonin; mephedrone, MDPV, methylone
Schifano F, Chiappini S, Miuli A, et al. New psychoactive substances (NPS) and serotonin syndrome onset: a systematic review. Exp Neurol 2021;339:113638. — serotonin syndrome reports with mephedrone, MDPV, methylone, butylone

Record history

v2026.10.02First published.
2026-10-02Last reviewed against its sources.

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