Trihexyphenidyl

Clinical contraindication: None listed; No clinical contraindication identified.
Best available evidence: Mechanism only; Also: standard practice.
Half-life: Not recorded

Named in state rules?

CONot named

ORNot named

NMPending

Cite asPsilodex: trihexyphenidyl · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Th · Pr

Anticholinergic: heart-rate rise, reduced sweating, added confusion or delirium risk.

Human data with psilocybin: None known: no published human data with psilocybin

Evidence types on this record

ThMechanism only (theoretical)

PrStandard practice; no psilocybin-specific data

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Anticholinergic: Blocks acetylcholine. Can cause a fast heart rate, dry mouth, reduced sweating and heat intolerance, and confusion, more so at high doses or in combination. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

Often prescribed for antipsychotic side effectsCO 2.2(A)(6)–(7)

05 Sources

Trihexyphenidyl Hydrochloride Tablet · FDA label (DailyMed)

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