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PsilodexMedication × psilocybin
Your list 00
Psychotropics
Brand names
Cobenfy
Reviewed 2026-10-01

Xanomeline–trospium

Clinical contraindication
Relative
Substantial clinical concern; the literature treats it as a reason for caution or deferral.
Best available evidence
Mechanism only
Half-life
Not recorded
Named in state rules?
CONamed
ORNot named
NMPending
Cite asPsilodex: xanomeline-trospium · v2026.10.02

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

01 Interaction with psilocybin

Th

No dopamine or 5-HT2A blockade; effect on psilocybin unknown. Nausea, vomiting and raised heart rate are common; trospium is anticholinergic.

Human data with psilocybin
None known: no published human data with psilocybin
Evidence types on this record
ThMechanism only (theoretical)

02 Pharmacology relevant to psilocybin

2 listed · counted on reports
Anticholinergic
Blocks acetylcholine. Can cause a fast heart rate, dry mouth, reduced sweating and heat intolerance, and confusion, more so at high doses or in combination. Sources [1]
Raises blood pressure or heart rate
Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Named · 2.2(A)(6)–(7) · 2.5(A)(2)

Treated as an antipsychotic medication under the rule (FDA-approved for schizophrenia), although it does not block dopamine receptors. Antipsychotic medications are named in rule, regardless of indication or dose. A Facilitator licensee may not provide services to a participant taking one without a referral for natural medicine services from a licensed provider, medical clearance from their medical or behavioral health provider, or a consultation and risk review with a medical or behavioral health provider. A Clinical Facilitator who does not prescribe antipsychotics within their secondary license needs clearance from, or a consultation and risk review with, such a provider.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-09-30

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

  • Schizophrenia (indication)CO 2.5(A)(2) · OR 333-333-5050(3)(j)

05 Sources

1
  1. Cobenfy (Xanomeline And Trospium Chloride) Capsule, Coated Pellets Cobenfy (Xanomeline And · FDA label (DailyMed)

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Before you startTerms v2026-10-01

What Psilodex is, and isn't.

  1. 01It summarises published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Starting, stopping, or changing a medication is the prescriber's decision. Bring the report to them.
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