How Psilodex is built.
What each record contains, what the codes mean, where the information comes from, and how it is kept current.
A single administration session with natural psilocybin mushrooms in a state-regulated program: Colorado, Oregon and New Mexico. For each of 480 medications, supplements and substances: what is known about it with psilocybin, and what each state's rules say.
Not medical advice, a screening decision, or clearance to participate. It does not rate a medication, recommend a change, or say whether someone can take part. Starting, stopping, or changing a medication is the prescriber's decision.
| Code | Meaning | Used in |
|---|---|---|
| RCT | Controlled trial | 6 records |
| OL | Open-label trial | 5 records |
| CR | Case reports or online surveys | 22 records |
| XP | Human data with another classic psychedelic (e.g. LSD), not psilocybin; named in the text | 13 records |
| Th | Mechanism only (theoretical) | 188 records |
| Pr | Standard practice; no psilocybin-specific data | 277 records |
Most records rest on mechanism or standard practice because few medications have been studied with psilocybin. A record's code describes the evidence; it is not a grade of safety.
| Absolute | The clinical literature treats the combination as contraindicated. | 11 records |
| Relative | Substantial clinical concern; the literature treats it as a reason for caution or deferral. | 48 records |
| None listed | No clinical contraindication identified. With mechanism-only evidence, this reflects how little has been studied, not a finding of safety. | 421 records |
| Named | A provision names this medication or its class. |
| Not named | No provision names this medication or its class. |
| Unsettled | Whether a provision applies to this medication is unsettled. |
| Pending | Rules are not final; no provision naming this medication has been found. |
Rule text is checked against the official source; each state shows when it was last checked on the Sources page.
Each flag on a record is supported by a cited source. On the report, flags are counted across the whole list (for example, “Serotonergic · 2 / 4”) so overlapping properties are visible. A count is not a score.
Every record carries at least one public citation, and every flag is supported by a source that states it: an FDA label, a reference textbook page, a peer-reviewed paper or a government page. “No reported interaction” means the medication does not appear in the systematic reviews of psychedelic interactions, and is cited to those reviews. The data does not build if any record or flag lacks a source. All sources →
Scheduled checks look for new FDA labels, state rule changes and new papers. Findings go to a review queue, never straight into the data.
Each change is checked against its source, with a second clinical reviewer for any change to a clinical level, evidence code or state rule.
The data is validated before release: every record needs a citation, every flag a source, no instruction-style wording.
A new dated version is published with a plain-language changelog. Earlier versions stay downloadable.
- Most interaction evidence is thin: case reports, surveys, mechanism, or data from LSD rather than psilocybin.
- Doses, timing, other medications and health conditions change how any combination plays out. A record cannot account for them.
- A medication missing from the database is not a sign it is safe.
- Rule summaries help find the right provision; the official rule text governs.
Tell us what's wrong and, if you can, the source. Please don't include anything about yourself or anyone else's health. Accepted fixes appear in the changelog.