Felodipine

A calcium channel blocker blood pressure medicine (extended-release), FDA-approved for hypertension.

psilodex.org/m/felodipine · data v2026.10.05

Clinical contraindication: None listed; No label contraindication covering psilocybin was found. This is not a finding that the combination has been shown to be without risk.
Psilocybin evidence: No psilocybin data
Half-life: ~11–16 h; Approximate, in adults. Source under Interaction below.

Named in state rules?

Not namedColorado Condition rules (3)

Not namedOregon

PendingNew Mexico

Cite asPsilodex, “Felodipine”, v2026.10.05. psilodex.org/m/felodipine

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

What it is used for

FDA status

FDA-approved

Availability

Generic only in US (extended-release)

FDA-approved for

High blood pressure (hypertension)

Sources [1]

01 Interaction with psilocybin

It lowers blood pressure, so it may lessen psilocybin's blood pressure rise (not studied with psilocybin).

Detail Felodipine lowers blood pressure, so it may lessen psilocybin's blood pressure rise (no psilocybin data). Also, its label notes it may occasionally cause significant low blood pressure and a reflex fast heart rate.

Human data with psilocybin: No psilocybin data; based on how it works and its label
Half-life: ~11–16 h (terminal) (FDA label, checked 2026-10-04) Terminal half-life measured with the immediate-release formulation; US product is extended-release.

Evidence types on this record

No psilocybin dataNo psilocybin data: no human data with psilocybin or another classic psychedelic; the text draws on the medication's own pharmacology and its label or reference facts

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Lowers blood pressure or causes orthostasis: Lowers blood pressure, or causes a drop on standing (orthostasis) that can bring dizziness or fainting. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not namedCondition rules (3)

No provision names this medication or its class.

Colorado · checked 2026-10-04

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-10-04

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-04

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

Hypertension (provision applies if uncontrolled)
- CO 2.5(A)(2) · Clinical Facilitator licensees
- CO 6.16(F)(2)(a) · Facilitators without a clinical facilitator license
- CO 6.16(F)(1) · All licensees

05 Sources

Felodipine Extended-Release Tablets, USP (Torrent) · FDA label (DailyMed) — Lowers blood pressure or causes orthostasis: Precautions: Hypotension "Felodipine, like other calcium antagonists, may occasionally precipitate significant hypotension and, rarely, syncope." | Clinical Pharmacology "Following oral administration of the immediate-release formulation, the plasma level of felodipine also declined polyexponentially with a mean terminal t 1/2 of 11 to 16 hours." | revised 2026-02

Record history

v2026.10.02First published.
2026-10-04Last reviewed against its sources.

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