Supplements and over the counter

Brand names
Claritin-D 12 Hour, Claritin-D 24 Hour, Alavert Allergy and Congestion D-12

Loratadine–pseudoephedrine

An over-the-counter antihistamine (loratadine) plus decongestant (pseudoephedrine) tablet for allergy symptoms with nasal and sinus congestion.

psilodex.org/m/loratadine-pseudoephedrine · data v2026.10.05

Clinical contraindication: None listed; No label contraindication covering psilocybin was found. This is not a finding that the combination has been shown to be without risk.
Psilocybin evidence: No psilocybin data
Half-life: 4–6 h; Approximate, in adults. Source under Interaction below.

Named in state rules?

Not namedColorado

Not namedOregon

PendingNew Mexico

Cite asPsilodex, “Loratadine–pseudoephedrine”, v2026.10.05. psilodex.org/m/loratadine-pseudoephedrine

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

What it is used for

FDA status

FDA-approved

FDA-approved for

Allergy symptoms (sneezing, runny nose, itchy or watery eyes, itchy nose or throat)
Nasal and sinus congestion and pressure from colds or allergies

Sources [1]

01 Interaction with psilocybin

Its pseudoephedrine may raise blood pressure and heart rate, adding to psilocybin's brief rise; loratadine has no known psilocybin interaction.

Detail Pseudoephedrine is a sympathomimetic (adrenaline-like) decongestant that may raise blood pressure and heart rate. This could add to psilocybin's brief rise (no psilocybin data). Loratadine alone has no known interaction. Separately, its Drug Facts label warns against use with a prescription MAOI (an antidepressant type) or within 2 weeks after one. It lists nervousness, dizziness and sleeplessness as effects that warrant stopping. Sources [1]

Human data with psilocybin: No psilocybin data; based on how it works and its label
Half-life: pseudoephedrine 4–6 h (FDA label, checked 2026-10-04) Pseudoephedrine value from the Allegra-D 12 Hour label; depends on urine pH. Loratadine half-life not stated in the fetched labels. The over-the-counter Claritin-D label gives no loratadine half-life.

Evidence types on this record

No psilocybin dataNo psilocybin data: no human data with psilocybin or another classic psychedelic; the text draws on the medication's own pharmacology and its label or reference facts

02 Pharmacology relevant to psilocybin

1 listed · counted on reports

Raises blood pressure or heart rate: Raises blood pressure or heart rate. Psilocybin raises both for several hours, so the effects can add. Sources [1]

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-10-04

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-10-04

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-04

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

Claritin-D 12 Hour (loratadine and pseudoephedrine sulfate) - Drug Facts · FDA label (DailyMed) — Raises blood pressure or heart rate: Warnings "Ask a doctor before use if you have heart disease thyroid disease high blood pressure diabetes" | "if you are now taking a prescription monoamine oxidase inhibitor (MAOI)" | "nervousness, dizziness or sleeplessness occurs"
ALLEGRA-D 12 HOUR (fexofenadine and pseudoephedrine) - pseudoephedrine pharmacokinetics · FDA label (DailyMed) — Elimination: "Pseudoephedrine has been shown to have a mean elimination half-life of 4-6 hours which is dependent on urine pH."
Halman A, Kong G, Sarris J, Perkins D. Drug–drug interactions involving classic psychedelics: a systematic review. J Psychopharmacol 2024;38(1):3–18. — no reported interaction
Sarparast A, Thomas K, Malcolm B, Stauffer CS. Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review. Psychopharmacology 2022;239(6):1945–1976. — no reported interaction

Record history

v2026.10.02First published.
2026-10-04Last reviewed against its sources.

Report an error in this record →