Norgestrel

A progestin-only birth control pill (0.075 mg), FDA-approved for sale without a prescription to prevent pregnancy.

psilodex.org/m/norgestrel · data v2026.10.05c

Clinical contraindication: None listed; No label contraindication covering psilocybin was found. This is not a finding that the combination has been shown to be without risk.
Psilocybin evidence: No psilocybin data
Half-life: Not stated in label or references

Named in state rules?

Not namedColorado

Not namedOregon

PendingNew Mexico

Cite asPsilodex, “Norgestrel”, v2026.10.05c. psilodex.org/m/norgestrel

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

What it is used for

FDA status

FDA-approved

Availability

OTC

FDA-approved for

Pregnancy prevention (over-the-counter progestin-only pill, 0.075 mg)

Sources [1]

01 Interaction with psilocybin

Not studied with psilocybin, and no mechanism linking them has been described.

Detail Not studied with psilocybin, and no mechanism linking them has been described. Norgestrel is a progestin; its active form is levonorgestrel. This 0.075 mg progestin-only pill has no estrogen, so the estrogen effect on psilocin clearance noted for combined pills does not apply. Also, its label states that enzyme-inducing drugs such as carbamazepine, rifampin and St. John's wort make it less effective. Sources [1][2]

Human data with psilocybin: No psilocybin data; based on its label

Evidence types on this record

No psilocybin dataNo psilocybin data: no human data with psilocybin or another classic psychedelic; the text draws on the medication's own pharmacology and its label or reference facts

02 Pharmacology relevant to psilocybin

None listed

No pharmacology properties of concern are listed for this record.

03 State rules

Plain-language summary · official text governs

CO4 CCR 755-1

Not named

No provision names this medication or its class.

Colorado · checked 2026-10-04

OROAR 333-333

Not named

No provision names this medication or its class.

Oregon · checked 2026-10-04

NM7.35.3 NMAC (proposed)

Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-04

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

Contraceptive use (0.075 mg over-the-counter progestin-only pill; no rule applies)

05 Sources

OPILL (norgestrel) tablet 0.075 mg - Drug Facts · FDA label (DailyMed) — Uses "To prevent pregnancy"; Ask a doctor before use if taking seizure, tuberculosis or HIV medicines or St. John's wort (label rev. 2025-01-27).
Opill (norgestrel tablets) 0.075 mg - prescription label, 2017 · FDA label (DailyMed) — "The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as phenytoin, carbamazepine, barbiturates, rifampin, efavirenz, bosentan and herbal preparations containing St. John's Wort"; serum levels near baseline by 24 hours; no half-life value stated.
Halman A, Kong G, Sarris J, Perkins D. Drug–drug interactions involving classic psychedelics: a systematic review. J Psychopharmacol 2024;38(1):3–18. — no reported interaction
Sarparast A, Thomas K, Malcolm B, Stauffer CS. Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review. Psychopharmacology 2022;239(6):1945–1976. — no reported interaction

Record history

v2026.10.05cFirst published.
2026-10-05Last reviewed against its sources.

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