PsilodexMedication × psilocybin
Your list , 0 items
General prescriptions
Brand names
—
Reviewed 2026-10-04

Propafenone

A Class IC antiarrhythmic, FDA-approved to delay recurrence of paroxysmal atrial fibrillation or PSVT without structural heart disease, and for life-threatening ventricular arrhythmias.

psilodex.org/m/propafenone · data v2026.10.05

Clinical contraindication
None listed
No label contraindication covering psilocybin was found. This is not a finding that the combination has been shown to be without risk.
Psilocybin evidence
No psilocybin data
Half-life
2–10 h
Approximate, in adults. Source under Interaction below.
Named in state rules?
Not namedColorado Condition rules (3)
Not namedOregon
PendingNew Mexico
Cite asPsilodex, “Propafenone”, v2026.10.05. psilodex.org/m/propafenone

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

What it is used for

FDA status

FDA-approved

FDA-approved for
  • Paroxysmal atrial fibrillation or flutter recurrence (no structural heart disease)
  • Paroxysmal supraventricular tachycardia (PSVT) recurrence (no structural heart disease)
  • Life-threatening ventricular arrhythmias
Sources [1]
Other safety

Boxed warning: increased mortality with Class IC antiarrhythmics in the CAST trial after heart attack; use is limited to people without structural heart disease for atrial arrhythmias.

About the medication itself, separate from any interaction with psilocybin.

Sources [1]

01 Interaction with psilocybin

ND

Not studied with psilocybin; it affects heart rhythm, and psilocybin briefly raises heart rate and blood pressure.

Detail Propafenone is a Class IC antiarrhythmic (heart-rhythm drug) with beta-blocking activity. It can cause new or worsened arrhythmias (irregular heartbeats) and may prolong the QT interval (a heart-rhythm measure). Psilocybin transiently raises heart rate and blood pressure. The body metabolizes propafenone itself by CYP2D6, CYP3A4 and CYP1A2 (liver enzymes). No psilocybin data exist. Sources [1]

Human data with psilocybin
No psilocybin data; based on how it works and its label
Half-life
2–10 h (most people); 10–32 h in CYP2D6 poor metabolizers (FDA label, checked 2026-10-04)
Evidence types on this record
No psilocybin dataNo psilocybin data: no human data with psilocybin or another classic psychedelic; the text draws on the medication's own pharmacology and its label or reference facts

02 Pharmacology relevant to psilocybin

1 listed · counted on reports
QT-prolonging
Lengthens the QT interval on an ECG, a measure of the heart’s electrical recovery between beats. A long QT raises the risk of a dangerous heart rhythm, more so with other QT-prolonging drugs or low potassium or magnesium. Sources [1]

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not namedCondition rules (3)

No provision names this medication or its class.

Colorado · checked 2026-10-04
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-10-04
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-04

04 Conditions to ask about

Screening items in state rules

This medication is usually taken for a condition. State rules screen for some conditions directly, so the medication is a prompt to ask about them. Confirm with the participant; never assume a condition from the medication.

  • Cardiovascular disease likely
    • CO 2.5(A)(2) · Clinical Facilitator licensees
    • CO 6.16(F)(2)(a) · Facilitators without a clinical facilitator license
    • CO 6.16(F)(1) · All licensees

05 Sources

1
  1. Propafenone hydrochloride tablets (Strides) · FDA label (DailyMed) — revised 2026-05 | QT-prolonging: 5.1 Proarrhythmic Effects "It may also worsen premature ventricular contractions or supraventricular arrhythmias, and it may prolong the QT interval." | 5.4 "Propafenone is metabolized by CYP2D6, CYP3A4, and CYP1A2 isoenzymes." | 12.3 "In over 90% of patients, the drug is rapidly and extensively metabolized with an elimination half-life from 2 to 10 hours." "In these patients, the estimated propafenone elimination half-life ranges from 10 to 32 hours."

Record history

  • v2026.10.02First published.
  • 2026-10-04Last reviewed against its sources.

Report an error in this record →

Before you startTerms 2026-10-01

What Psilodex is, and isn't.

  1. 01Psilodex summarizes published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Psilodex presents information only. Do not stop or change a medication without talking with the prescriber. Bring the report to them.
  3. 03Your searches and list stay in this browser and are not sent to us. Opening a medication's page is an ordinary web request, so our hosting providers see which page was opened. What we can and can't see.

In an emergency, call 911. For a mental health crisis, call or text 988. Full terms and privacy.