PsilodexMedication × psilocybin
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Supplements and over the counter
Brand names
SPM Active, Pro-Resolving Mediators
Reviewed 2026-10-03

Specialized pro-resolving mediators (SPMs)

A fish-oil-derived dietary supplement standardized to omega-3 lipid compounds (17-HDHA, 18-HEPE); not FDA-approved for any condition.

psilodex.org/m/specialized-pro-resolving-mediators · data v2026.10.04

Clinical contraindication
None listed
No clinical contraindication identified.
Psilocybin evidence
No psilocybin data
Half-life
Not stated in label or references
Named in state rules?
Not namedColorado
Not namedOregon
PendingNew Mexico
Cite asPsilodex, “Specialized pro-resolving mediators (SPMs)”, v2026.10.04. psilodex.org/m/specialized-pro-resolving-mediators

Clinical data and state rules are separate facts. Both are shown; neither is a decision.

What it is used for

FDA status

Not FDA-approved

Availability

Dietary supplement

Sources [1]

01 Interaction with psilocybin

PR

No known interaction with psilocybin; these are fish-oil products standardized to omega-3-derived compounds, with no psilocybin data.

Detail No known interaction with psilocybin. SPM supplements are fractionated marine oils standardized to omega-3-derived lipid mediators (17-HDHA, 14-HDHA, 18-HEPE); there are no psilocybin-specific data. Sources [1]

No reported interaction is not a finding of safety: most combinations with psilocybin have never been studied.

Human data with psilocybin
None known: no published human data with psilocybin
Evidence types on this record
No psilocybin dataNo psilocybin data; record based on general references (product label, reference works, reviews)

02 Pharmacology relevant to psilocybin

None listed

No pharmacology properties of concern are listed for this record.

03 State rules

Plain-language summary · official text governs
CO4 CCR 755-1
Not named

No provision names this medication or its class.

Colorado · checked 2026-09-30
OROAR 333-333
Not named

No provision names this medication or its class.

Oregon · checked 2026-09-30
NM7.35.3 NMAC (proposed)
Pending

New Mexico's clinical rules (proposed 7.35.3 NMAC) are not final. No provision naming this medication has been found.

New Mexico · checked 2026-10-02

04 Conditions to ask about

None linked

No condition named in state rules is linked to this medication.

05 Sources

3
  1. Regidor PA, et al. Pro-Resolving Inflammatory Effects of a Marine Oil Enriched in Specialized Pro-Resolving Mediators (SPMs) Supplement and Its Implication in Patients with Post-COVID Syndrome (PCS). Biomedicines. 2024;12:2221. doi:10.3390/biomedicines12102221
  2. Halman A, Kong G, Sarris J, Perkins D. Drug–drug interactions involving classic psychedelics: a systematic review. J Psychopharmacol 2024;38(1):3–18. — no reported interaction
  3. Sarparast A, Thomas K, Malcolm B, Stauffer CS. Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review. Psychopharmacology 2022;239(6):1945–1976. — no reported interaction

Record history

  • v2026.10.02First published.
  • 2026-10-03Last reviewed against its sources.

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Before you startTerms 2026-10-01

What Psilodex is, and isn't.

  1. 01Psilodex summarizes published evidence and public state rules. It does not decide whether you can safely use psilocybin or take part in services, and it is not medical advice.
  2. 02Psilodex presents information only. Do not stop or change a medication without talking with the prescriber. Bring the report to them.
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